Author/Authors :
Jens-Uwe Peters، نويسنده , , Daniel Hunziker، نويسنده , , Holger Fischer، نويسنده , , Manfred Kansy، نويسنده , , Silja Weber، نويسنده , , Stéphane Kritter، نويسنده , , Aranka Müller، نويسنده , , Angelina Wallier، نويسنده , , Fabienne Ricklin، نويسنده , , Markus Boehringer، نويسنده , , Sonia Maria Poli، نويسنده , , Miklos Csato، نويسنده , , Bernd-Michael Loeffler، نويسنده ,
Abstract :
A recently identified DPP-IV inhibitor (1) was found to induce phospholipidosis and to inhibit CYP3A4. A small series of less lipophilic and less amphiphilic analogues was synthesized in an effort to overcome these issues. One compound from this series was equipotent to 1, did not induce phospholipidosis and showed a reduced CYP3A4 inhibition.
