Title of article
An aminomethylpyrimidine DPP-IV inhibitor with improved properties
Author/Authors
Jens-Uwe Peters، نويسنده , , Daniel Hunziker، نويسنده , , Holger Fischer، نويسنده , , Manfred Kansy، نويسنده , , Silja Weber، نويسنده , , Stéphane Kritter، نويسنده , , Aranka Müller، نويسنده , , Angelina Wallier، نويسنده , , Fabienne Ricklin، نويسنده , , Markus Boehringer، نويسنده , , Sonia Maria Poli، نويسنده , , Miklos Csato، نويسنده , , Bernd-Michael Loeffler، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2004
Pages
4
From page
3575
To page
3578
Abstract
A recently identified DPP-IV inhibitor (1) was found to induce phospholipidosis and to inhibit CYP3A4. A small series of less lipophilic and less amphiphilic analogues was synthesized in an effort to overcome these issues. One compound from this series was equipotent to 1, did not induce phospholipidosis and showed a reduced CYP3A4 inhibition.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2004
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
794639
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