Title of article :
(±)8-Amino-5,6,7,8-tetrahydroisoquinolines as novel antinociceptive agents
Author/Authors :
Malgorzata Dukat، نويسنده , , Mohamed Taroua، نويسنده , , Abdelaziz Dahdouh، نويسنده , , Umamaheswar Siripurapu، نويسنده , , M. Imad Damaj، نويسنده , , Billy R Martin، نويسنده , , Richard A. Glennon، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2004
Abstract :
Several amine-substituted 8-amino-5,6,7,8-tetrahydroisoquinolines were examined as conformationally-constrained analogs of the nicotinic cholinergic (nACh) 3-(aminomethyl)pyridines. Although these ligands failed to bind at nACh receptors, the N-ethyl-N-methyl analog 3d was found to be at least equipotent with nicotine in rodent tests of antinociception. The mechanism of action of 3d is currently unknown.
Keywords :
Analgesia , tail flick , fax: +1-804-828-7404 , Hot plate.* Corresponding author. Tel.: +1-804-828-8487 , e-mail: glennon@hsc.vcu.edu , Aminoisoquinolines
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
