Title of article
Antimitotic activity of glaupalol-related coumarins from Glaucidium palmatum
Author/Authors
Hiroshi Morita، نويسنده , , Tomoka Dota، نويسنده , , Junichi Kobayashi، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2004
Pages
4
From page
3665
To page
3668
Abstract
Two new coumarins, glaumacidines A (1) and B (2), and the related coumarins (3–7) have been isolated from the rhizomes of Glaucidium palmatum (Glaucidiaceae). The absolute configurations of 1 and 2 and trans- and cis-glaupadiols (3 and 4, respectively) were elucidated by spectroscopic data, chemical derivatization, and exciton chirality method. Glaupalol (5) enhanced the polymerization of tubulin and affected synergistically with paclitaxel on inhibition of KB cell proliferation.
Keywords
Antimitotic activity , coumarin , fax: +81-117064989 , e-mail: jkobay@pharm.hokudai.ac.jp , Glaucidium palmatum.* Corresponding author. Tel.: +81-117064985
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2004
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
794657
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