Author/Authors :
Tianbao Lu، نويسنده , , Thomas Markotan، نويسنده , , Frank Coppo، نويسنده , , Bruce Tomczuk، نويسنده , , Carl Crysler، نويسنده , , Stephen Eisennagel، نويسنده , , John Spurlino، نويسنده , , Lisa Gremminger، نويسنده , , Richard M. Soll، نويسنده , , Edward C Giardino، نويسنده , , Roger Bone، نويسنده ,
Abstract :
Through structure-based drug design and parallel synthesis, we have discovered a novel series of nonpeptidic phenyl-based thrombin inhibitors using oxyguanidines as guanidine bioisosteres. These compounds have been found to be highly potent, highly selective, and orally bioavailable.
Keywords :
structure-based drugdesign , Parallel synthesis. , Oxyguanidine , Thrombin inhibitor
