Author/Authors :
Zhen-Qiang Tan، نويسنده , , Elizabeth T. Birzin، نويسنده , , Wanda Chan، نويسنده , , Yi Tien Yang، نويسنده , , Lee-Yuh Pai، نويسنده , , Edward C Hayes، نويسنده , , Carolyn A DaSilva، نويسنده , , Frank DiNinno، نويسنده , , Susan P Rohrer، نويسنده , , James M. Schaeffer، نويسنده , , Milton L. Hammond، نويسنده ,
Abstract :
Dihydrobenzodithiin compounds (1–6) were prepared to explore the expansion of the dihydrobenzoxathiin lead compounds I–III as SERAMs (Selective Estrogen Receptor Alpha Modulators). The dihydrobenzodithiin compounds generally maintained a high degree of selectivity for ERα over ERβ, however, they lacked the in vivo antagonism/agonism activity exhibited by the lead class in an immature rat uterine growth model.
Keywords :
SERAM.* Corresponding author. Tel.: +1-732-594-1276 , fax: +1-732-594-9556 , e-mail: qiang_tan@merck.com , Estrogen receptor , SERM , Dihydrobenzodithiins
