Title of article :
(+)-3-[2-(Benzo[b]thiophen-2-yl)-2-oxoethyl]-1-azabicyclo[2.2.2]octane as potent agonists for the α7 nicotinic acetylcholine receptor
Author/Authors :
Ryo Tatsumi، نويسنده , , Kohji Seio، نويسنده , , Masakazu Fujio، نويسنده , , Jiro Katayama، نويسنده , , Takashi Horikawa، نويسنده , , Kenji Hashimoto، نويسنده , , Hiroshi Tanaka ، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2004
Abstract :
A series of 3-substituted 1-azabicyclo[2.2.2]octanes was discovered as the α7 nicotinic acetylcholine (α7) receptor agonists. It was found that (+)-3-[2-(benzo[b]thiophen-2-yl)-2-oxoethyl]-1-azabicyclo[2.2.2]octane (+)-15b has potent agonistic activity for the α7 receptor.
Keywords :
a7 Nicotinic acetylcholine receptor.* Corresponding author. Tel.: +81-459634414 , e-mail: Tatsumi.Ryo@mg.m-pharma.co.jp , fax: +81-459634211
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
