Title of article
Design, synthesis, and evaluation of estradiol-linked genotoxicants as anti-cancer agents
Author/Authors
U Sharma، نويسنده , , J.C Marquis، نويسنده , , A. Nicole Dinaut، نويسنده , , S.M Hillier، نويسنده , , B Fedeles، نويسنده , , P.T Rye، نويسنده , , J.M Essigmann، نويسنده , , R.G Croy، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2004
Pages
5
From page
3829
To page
3833
Abstract
A series of bifunctional compounds was prepared consisting of 17β estradiol linked to a DNA damaging N,N-bis-(2-chloroethyl)aniline. The objective of our studies was to determine the characteristics of the linker that permitted both reaction with DNA and binding of the resultant covalent adducts to the estrogen receptor. Linker characteristics were pivotal determinants underlying the ability of the compounds to kill selectively breast cancer cells that express the estrogen receptor.
Keywords
anti-cancer , Steroid–mustard conjugates , Breast cancer.* Corresponding authors. Tel.: +1-617-2536227 , fax: +1-617-2535445 , e-mail addresses: jessig@mit.edu , rgcroy@mit.edu
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2004
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
794690
Link To Document