Title of article
Synthesis and biological activity of 22-oxa CD-ring modified analogues of 1α,25-dihydroxyvitamin D3: spiro[5.5]undecane CF-ring analogues
Author/Authors
Wim Schepens، نويسنده , , Dirk Van Haver، نويسنده , , Maurits Vandewalle، نويسنده , , Pierre J. De Clercq، نويسنده , , Roger Bouillon، نويسنده , , Annemieke Verstuyf، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2004
Pages
4
From page
3889
To page
3892
Abstract
The synthesis and biological activity of novel CD-ring modified analogues of 22-oxa-1α,25-dihydroxyvitamin D3, lacking the D-ring and featuring a connection between C-18 and C-21 (spiro[5.5]undecane CF-ring analogues), is described. The central ring system is conveniently synthesised from an achiral intermediate. The analogues have marginal binding affinity for the nVDR and possess low to moderate genomic activity.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2004
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
794700
Link To Document