Title of article
Synthesis and biological evaluation of the major metabolite of atomoxetine: elucidation of a partial κ-opioid agonist effect
Author/Authors
Christopher J Creighton، نويسنده , , Kris Ramabadran، نويسنده , , Patrick E Ciccone، نويسنده , , Jingchun Liu، نويسنده , , Michael J Orsini، نويسنده , , Allen B. Reitz، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2004
Pages
3
From page
4083
To page
4085
Abstract
The major human metabolite of atomoxetine (4-hydroxyatomoxetine) was tested against a panel of receptors and enzymes, and was found to interact with the μ, δ, and κ-opioid receptors based upon studies involving both binding and functional assays. 4-Hydroxyatomoxetine was determined to be a partial agonist of the κ-opioid receptor.
Keywords
Atomoxetine , metabolism , j-Opioid.* Corresponding authors. Tel.: +1-215-628-5348 , fax: +1-215-628-49-85 , e-mail: ccreight@prdus.jnj.com
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2004
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
794740
Link To Document