Title of article :
Phenylhomophthalimide-type NOS inhibitors derived from thalidomide
Author/Authors :
Tomomi Noguchi، نويسنده , , Hiroko Sano، نويسنده , , Rumiko Shimazawa، نويسنده , , Aya Tanatani، نويسنده , , Hiroyuki Miyachi، نويسنده , , Yuichi Hashimoto، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2004
Abstract :
Thalidomide shows moderate inhibitory activity toward neuronal nitric oxide synthase (nNOS) and inducible NOS (iNOS), but not toward endothelial NOS (eNOS). Structural development studies of thalidomide yielded novel phenylhomophthalimide-type NOS inhibitors with enhanced activity and different subtype selectivity.
Keywords :
NOS inhibitors , thalidomide , Structural development.* Corresponding author. E-mail: bmcyfh@iam.u-tokyo.ac.jp
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
