Title of article
Phenylhomophthalimide-type NOS inhibitors derived from thalidomide
Author/Authors
Tomomi Noguchi، نويسنده , , Hiroko Sano، نويسنده , , Rumiko Shimazawa، نويسنده , , Aya Tanatani، نويسنده , , Hiroyuki Miyachi، نويسنده , , Yuichi Hashimoto، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2004
Pages
5
From page
4141
To page
4145
Abstract
Thalidomide shows moderate inhibitory activity toward neuronal nitric oxide synthase (nNOS) and inducible NOS (iNOS), but not toward endothelial NOS (eNOS). Structural development studies of thalidomide yielded novel phenylhomophthalimide-type NOS inhibitors with enhanced activity and different subtype selectivity.
Keywords
NOS inhibitors , thalidomide , Structural development.* Corresponding author. E-mail: bmcyfh@iam.u-tokyo.ac.jp
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2004
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
794750
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