Title of article
Bile acid conjugates of a nonsteroidal glucocorticoid receptor modulator
Author/Authors
Noah Tu، نويسنده , , J.T Link، نويسنده , , Bryan K. Sorensen، نويسنده , , Maurice Emery، نويسنده , , Marlena Grynfarb، نويسنده , , Annika Goos-Nilsson، نويسنده , , Thao Bach Nguyen، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2004
Pages
5
From page
4179
To page
4183
Abstract
Bile acid conjugates of a selective nonsteroidal glucocorticoid receptor modulator were prepared and evaluated. Potent GR binding conjugates that showed improved metabolic stability were discovered. However, cellular potency and pharmacokinetics were not substantially improved.
Keywords
Conjugate.* Corresponding author. Tel.: +1-847-935-6806 , fax: +1-847-938-1674 , Glucocorticoid receptor modulator , e-mail: james.link@abbott.com , bile acid
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2004
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
794758
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