Title of article
Factor Xa inhibitors based on a 2-carboxyindole scaffold: SAR of neutral P1 substituents
Author/Authors
Marc Nazaré، نويسنده , , Melanie Essrich، نويسنده , , David W Will، نويسنده , , Hans Matter، نويسنده , , Kurt Ritter، نويسنده , , Matthias Urmann، نويسنده , , Armin Bauer، نويسنده , , Herman Schreuder، نويسنده , , Angela Dudda، نويسنده , , Jorg Czech، نويسنده , , Martin Lorenz، نويسنده , , Volker Laux، نويسنده , , Volkmar Wehner، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2004
Pages
5
From page
4191
To page
4195
Abstract
A series of novel, highly potent 2-carboxyindole-based factor Xa inhibitors is described. Structural requirements for neutral ligands, which bind in the S1 pocket of factor Xa were investigated with the 2-carboxyindole scaffold. This privileged fragment assembly approach yielded a set of equipotent, selective inhibitors with structurally diverse neutral P1 substituents.
Keywords
e-mail: marc.nazare@aventis.com , Factor Xa inhibitors.* Corresponding author. Tel.: +49-69-305-15150 , fax: +49-69-331-399
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2004
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
794760
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