Author/Authors :
Derek J Denhart، نويسنده , , Ashok V Purandare، نويسنده , , John D. Catt، نويسنده , , H. Dalton King، نويسنده , , Aiming Gao، نويسنده , , Jeffrey A. Deskus، نويسنده , , Michael A. Poss، نويسنده , , Arlene D Stark، نويسنده , , John R Torrente، نويسنده , , Graham Johnson، نويسنده , , Ronald J. Mattson، نويسنده ,
Abstract :
The present studies have identified a series of diaminopyrimidines and diaminopyridines as novel 5-HT7 receptor ligands. Three regiosiomeric classes of pyrimidines and four regioisomeric classes of pyridines were synthesized and analyzed for binding to the 5-HT7 receptor. The 5-HT7 binding affinities of different regioisomers show clearly the structure–activity relationship with position of ring nitrogens.
