Title of article :
Acyl-CoA: cholesterol acyltransferase inhibitory activities of fatty acid amides isolated from Mylabris phalerate Pallas
Author/Authors :
Ming-Zhe Xu، نويسنده , , Woo Song Lee، نويسنده , , Mi-Jeong Kim، نويسنده , , Doo-Sang Park، نويسنده , , Hana Yu، نويسنده , , Guan Rong Tian، نويسنده , , Tae-Sook Jeong، نويسنده , , Ho-Yong Park، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2004
Abstract :
Unsaturated fatty acid amides, 9(Z)-octadecenamide (2) and 9(Z),12(Z)-octadecadienamide (4) as inhibitors of acyl-CoA: cholesterol acyltransferase (ACAT) were isolated from the ethyl acetate extracts of the insect, Mylabris phalerate Pallas, and elucidated by their spectroscopic data analysis. Compounds 2 and 4 inhibited rat liver microsomal ACAT, hACAT-1, and hACAT-2 with IC50 values of 170, 85, and 63 μM for 2 and of 151, 53, and 45 μM for 4, respectively.
Keywords :
ACAT inhibitors , The insect , Mylabris phalerate Pallas.* Corresponding authors. Tel.: +82-42-860-4650/4558 , fax: +82-42-860-4659/861-2675 , e-mail addresses: hypark@kribb.re.kr , tsjeong@kribb.re.kr
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
