Author/Authors :
Hiroshi Ueno ، نويسنده , , Susumu Katoh، نويسنده , , Katsuyuki Yokota، نويسنده , , Jun-ichi Hoshi، نويسنده , , Mikio Hayashi، نويسنده , , Itsuo Uchida، نويسنده , , Kazuo Aisaka، نويسنده , , Yasunori Hase، نويسنده , , Hidetsura Cho، نويسنده ,
Abstract :
A series of benzimidazole derivatives with the side chain on the nitrogen atom oriented to the prime site of factor Xa (FXa) were designed and synthesized. Compounds with substituted aminocarbonylmethyl groups as the side chain showed potent FXa inhibitory activity. Compounds 1 and 2 exhibited most potent inhibitory activity and were effective as anticoagulants in a DIC model.
