Title of article
Stereoselective synthesis and preliminary evaluation of new d-3-heteroarylcarbonylalanines as ligands of the NMDA receptor
Author/Authors
Paulo G. Lima، نويسنده , , Rodrigo R.B. Caruso، نويسنده , , Simone O. Alves، نويسنده , , Renata F. Pessôa، نويسنده , , Dayde L. Mendonça-Silva، نويسنده , , Ricardo J. Nunes، نويسنده , , François Noël، نويسنده , , Newton G. Castro، نويسنده , , Paulo R.R. Costa، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2004
Pages
5
From page
4399
To page
4403
Abstract
New N-heteroarylcarbonylalanines of the d-series were stereoselectively prepared from enoates derived from d-mannitol. These compounds were active in binding and functional assays of the NMDA sub-type of glutamate receptors. A pyridine derivative inhibited MK801 binding, protected neurons from excitotoxic damage and blocked NMDA-induced currents in neurons. A thiophene derivative positively modulated the NMDA receptor, possibly through the allosteric glycine site.
Keywords
NMDA , fax: +55-21-25626733 , e-mail: ngcastro@farmaco.ufrj.br , lqb@nppn.ufrj.br , Glycine , Glutamate.* Corresponding authors. Tel.: +55-21-22804694 , Aminoacid
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2004
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
794801
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