Author/Authors :
Robert D Selliah، نويسنده , , Mark R Hellberg، نويسنده , , Najam A Sharif، نويسنده , , Marsha A McLaughlin، نويسنده , , Gary W Williams، نويسنده , , Daniel J. Scott، نويسنده , , David Earnest، نويسنده , , Karen S Haggard، نويسنده , , W Dennis Dean، نويسنده , , Pete Delgado، نويسنده , , Michael S Gaines، نويسنده , , Raymond E Conrow، نويسنده , , Peter G Klimko، نويسنده ,
Abstract :
A series of 11-oxa prostaglandin analogs was evaluated for FP receptor binding and activation. Several compounds having aryloxy-terminated lower chains were found to be potent agonists. Topical ocular dosing of AL-12182, the isopropyl ester prodrug of the potent agonist 13, lowered intraocular pressure in the monkey by 40% accompanied by minimal conjunctival hyperemia in the rabbit. AL-12182 was synthesized on multigram scale starting with d-sorbitol.
Keywords :
11-Oxa prostaglandin , Glaucoma.* Corresponding author. Tel.: +1-817-551-6932 , fax: +1-817-615-4696 , e-mail: peter.klimko@alconlabs.com
