Title of article :
Antibody light chain-catalyzed hydrolysis of a hepatitis C virus peptide
Author/Authors :
Hiroaki Taguchi، نويسنده , , Zhenyong Keck، نويسنده , , Steven K.H Foung، نويسنده , , Sudhir Paul، نويسنده , , Yasuhiro Nishiyama، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2004
Abstract :
A panel of human monoclonal and recombinant antibody light chains was screened for cleavage of the synthetic peptide corresponding to a neutralizing epitope of hepatitis C virus (residues 192–205 of envelope glycoprotein E1). One of the 39 light chains studied hydrolyzed the Val197–Ser198 bond of the peptide with Km and kcat values of 223 ± 7 μM and 0.087 ± 0.001 min−1.
Keywords :
peptidase , fax: +1-713-500-0574 , e-mail: yasuhiro.nishiyama@uth.tmc.edu , Hepatitis C virus.* Corresponding author. Tel.: +1-713-500-7342 , antibody
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
