Author/Authors :
K Shankaran، نويسنده , , Karla L. Donnelly، نويسنده , , Shrenik K. Shah، نويسنده , , Ravindra N. Guthikonda، نويسنده , , Malcolm MacCoss، نويسنده , , John L. Humes، نويسنده , , Stephen G. Pacholok، نويسنده , , Stephan K. Grant، نويسنده , , T.M Kelly، نويسنده , , K.K Wong، نويسنده ,
Abstract :
Syntheses and evaluation of pyrrolidin-2-imines and 1,3-thiazolidin-2-imines as inhibitors of nitric oxide synthase (NOS) are discussed. An extensive SAR was established for pyrrolidin-2-imines class of compounds. The amidines came out as the most potent inhibitors in addition to displaying selectivity.
Keywords :
Pyrrolidin-2-imine , NOS , 1 , 3-Thiazolidin-2-imine.q See Ref. 1.
