Author/Authors :
Kazuhiko Torisu، نويسنده , , Kaoru Kobayashi، نويسنده , , Maki Iwahashi، نويسنده , , Hiromu Egashira، نويسنده , , Yoshihiko Nakai، نويسنده , , Yutaka Okada، نويسنده , , Fumio Nanbu، نويسنده , , Shuichi Ohuchida، نويسنده , , Hisao Nakai، نويسنده , , Masaaki Toda، نويسنده ,
Abstract :
A series of Indomethacin analogs were synthesized and biologically evaluated. Among the compounds tested, N-(p-butoxy)benzoyl-2-methylindole-4-acetic acid 2 was discovered as a new chemical lead for a prostaglandin D2 (PGD2) receptor antagonist. Structure–activity relationship data are also presented.
Keywords :
Prostaglandin , DP receptor , Antagonist.* Corresponding author. Tel.: +81-75-961-1151 , e-mail: torisu@ono.co.jp , fax: +81-75-962-9314
