Title of article
Discovery of new chemical leads for prostaglandin D2 receptor antagonists
Author/Authors
Kazuhiko Torisu، نويسنده , , Kaoru Kobayashi، نويسنده , , Maki Iwahashi، نويسنده , , Hiromu Egashira، نويسنده , , Yoshihiko Nakai، نويسنده , , Yutaka Okada، نويسنده , , Fumio Nanbu، نويسنده , , Shuichi Ohuchida، نويسنده , , Hisao Nakai، نويسنده , , Masaaki Toda، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2004
Pages
6
From page
4557
To page
4562
Abstract
A series of Indomethacin analogs were synthesized and biologically evaluated. Among the compounds tested, N-(p-butoxy)benzoyl-2-methylindole-4-acetic acid 2 was discovered as a new chemical lead for a prostaglandin D2 (PGD2) receptor antagonist. Structure–activity relationship data are also presented.
Keywords
Prostaglandin , DP receptor , Antagonist.* Corresponding author. Tel.: +81-75-961-1151 , e-mail: torisu@ono.co.jp , fax: +81-75-962-9314
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2004
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
794832
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