Author/Authors :
Gary Pitt، نويسنده , , Andrzej Batt، نويسنده , , Robert Haigh، نويسنده , , Andrew Penson، نويسنده , , Peter Robson، نويسنده , , David Rooker، نويسنده , , André Tartar، نويسنده , , Julie Trim، نويسنده , , Christopher Yea، نويسنده , , Michael Roe، نويسنده ,
Abstract :
A library of compounds targeted to the vasopressin/oxytocin family of receptors was screened for activity at a cloned human oxytocin receptor using a reporter gene assay. Potency and selectivity were optimised to afford compound 39, EC50 = 33 nM. This series of compounds represents the first disclosed, non-peptide, low molecular weight agonists of the hormone oxytocin (OT).
Keywords :
e-mail: michael.roe@ferring-research.co.uk , Non-peptide , Male erectile dysfunction.* Corresponding author. Tel.: +44-2380-763400 , fax: +44-2380-766253 , Oxytocin agonist
