Author/Authors :
L.E. Wang، نويسنده , , Nan-Horng Lin، نويسنده , , Qun Li، نويسنده , , Rodger F. Henry، نويسنده , , Haiying Zhang، نويسنده , , Jerome Cohen، نويسنده , , Wen-Zhen Gu، نويسنده , , Kennan C. Marsh، نويسنده , , Joy L. Bauch، نويسنده , , Saul H. Rosenberg، نويسنده , , Hing L. Sham، نويسنده ,
Abstract :
Two novel series of potent and selective FTase inhibitors have been synthesized using structure-based design. Medicinal chemistry efforts led to the discovery of compound 4e with potent cellular activity and good oral bioavailability in dog. A synthetic route toward novel heterocycles 1,5-dimethyl-6-oxo-4-aryl-1,6-dihydro-pyridine-2-carbonitrile was established. The structure of compound 5c was confirmed by X-ray crystallography.
