Title of article
P1′ oxadiazole protease inhibitors with excellent activity against native and protease inhibitor-resistant HIV-1
Author/Authors
Ronald M. Kim، نويسنده , , Elizabeth A. Rouse، نويسنده , , Kevin T. Chapman، نويسنده , , William A. Schleif، نويسنده , , David B. Olsen، نويسنده , , Mark Stahlhut، نويسنده , , Carrie A. Rutkowski، نويسنده , , Emilio A. Emini، نويسنده , , James R. Tata، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2004
Pages
4
From page
4651
To page
4654
Abstract
HIV-1 protease inhibitors (PI’s) bearing 1,3,4-oxadiazoles at the P1′ position were prepared by a novel method involving the diastereoselective installation of a carboxylic acid and conversion to the P1′ heterocycle. The compounds are picomolar inhibitors of native HIV-1 protease, with most of the compounds maintaining excellent antiviral activity against a panel of PI-resistant strains.
Keywords
protease inhibitor , HIV.* Corresponding author. Tel.: +1-7325944847 , e-mail: ron_kim@merck.com , fax: +1-7325949464
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2004
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
794848
Link To Document