Author/Authors :
Vahid Alikhani، نويسنده , , David Beer، نويسنده , , David Bentley، نويسنده , , Ian Bruce، نويسنده , , Bernard M. Cuenoud، نويسنده , , Robin A. Fairhurst، نويسنده , , Peter Gedeck، نويسنده , , Sandra Haberthuer، نويسنده , , Claire Hayden، نويسنده , , Diana Janus، نويسنده , , Lynne Jordan، نويسنده , , Christine Lewis، نويسنده , , Kirsty Smithies، نويسنده , , Elke Wissler، نويسنده ,
Abstract :
The synthesis of a series of long-chain formoterol analogues in which the terminal ether residue of the β-phenethyl-amino-substituent has been extended beyond the methyl ether residue present in the parent compound are described. Evaluation of these analogues as β2-adrenoceptor agonists was used to provide an insight into the factors controlling the magnitude and duration of receptor activation.
