Author/Authors :
Srinivas Nanduri، نويسنده , , Vijay Kumar Nyavanandi، نويسنده , , Siva Sanjeeva Rao Thunuguntla، نويسنده , , Sridevi Kasu، نويسنده , , Mahesh Kumar Pallerla، نويسنده , , P. Sai Ram، نويسنده , , Sriram Rajagopal، نويسنده , , R. Ajaya Kumar، نويسنده , , Rajagopalan Ramanujam، نويسنده , , J. Moses Babu، نويسنده , , Krishnamurthi Vyas، نويسنده , , A. Sivalakshmi Devi، نويسنده , , G. Om Reddy، نويسنده , , Venkateswarlu Akella، نويسنده ,
Abstract :
Andrographolide 1, the cytotoxic agent of the plant Andrographis paniculata was subjected to semi-synthetic studies leading to the preparation of a number of potent and novel analogues. Of the analogues synthesized, while 8,17-epoxy andrographolide 6 retained the cytotoxic activity of 1, ester derivatives of 6 exhibited considerable improvement in activity. Lower activity was observed when the epoxy moiety in the triacetate 9, derived from 6 was modified. Synthesis and structure–activity relationships are discussed.
