Author/Authors :
Mark C. Noe، نويسنده , , Sheri L. Snow، نويسنده , , Lilli A. Wolf-Gouveia، نويسنده , , Peter G. Mitchell، نويسنده , , Lori Lopresti-Morrow، نويسنده , , Lisa M. Reeves، نويسنده , , Sue A. Yocum، نويسنده , , Jennifer L. Liras، نويسنده , , Marcie Vaughn، نويسنده ,
Abstract :
N-Hydroxy-3-hydroxy-4-arylsulfonyltetrahydropyranyl-3-carboxamides were designed as novel inhibitors of MMP-13 and aggrecanase based on known endocyclic hydroxamate inhibitors of matrix metalloproteinases. These compounds offer favorable physicochemical properties and low metabolic clearance. Synthesis and structure–activity relationships are reported.
