Title of article :
Synthesis of C8-linked pyrrolo[2,1-c][1,4]benzodiazepine–benzimidazole conjugates with remarkable DNA-binding affinity
Author/Authors :
Ahmed Kamal، نويسنده , , P. Ramulu، نويسنده , , O. Srinivas، نويسنده , , G. RAMESH، نويسنده , , P. Praveen Kumar، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2004
Abstract :
Two types of benzimidazoles have been synthesized and linked to DC-81 at C8-position through different alkyl chain spacers. These PBD conjugates have exhibited remarkable DNA-binding affinity, and a representative compound shows promising in vitro anticancer activity.
Keywords :
Pyrrolobenzodiazepine , benzimidazoles , Hoechst-33258 , DNA-binding ability , cytotoxicity.
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
