Title of article
N-(1-Benzylpyrrolidin-3-yl)arylbenzamides as potent and selective human dopamine D4 antagonists
Author/Authors
Ian Egle، نويسنده , , Nancy Barriault، نويسنده , , Michel Bordeleau، نويسنده , , Jillian Drage، نويسنده , , Laurence Dube، نويسنده , , Jack Peragine، نويسنده , , Lucy Mazzocco، نويسنده , , Jalaj Arora، نويسنده , , Keith Jarvie، نويسنده , , Ashok Tehim، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2004
Pages
4
From page
4847
To page
4850
Abstract
A series of N-(1-benzylpyrrolidin-3-yl)arylbenzamides 8 has been prepared, and their structure–activity relationships studied. Potent ligands selective for human D4 (hD4) over hD2 and α1 have been identified. One example was determined to be an antagonist in a cAMP assay, with an IC50 of 1500 nM.
Keywords
Dopamine , D4 antagonists.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2004
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
794885
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