Title of article
The identification and optimization of 2,4-diketobutyric acids as flap endonuclease 1 inhibitors
Author/Authors
L. Nathan Tumey، نويسنده , , Bayard Huck، نويسنده , , Elizabeth Gleason، نويسنده , , Jianmin Wang، نويسنده , , Daniel Silver، نويسنده , , Kurt Brunden، نويسنده , , Sherry Boozer، نويسنده , , Stephen Rundlett، نويسنده , , Bruce Sherf، نويسنده , , Steven Murphy، نويسنده , , Andrew Bailey، نويسنده , , Tom Dent، نويسنده , , Christina Leventhal، نويسنده , , John Harrington، نويسنده , , Youssef L. Bennani، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2004
Pages
4
From page
4915
To page
4918
Abstract
There have been several recent reports of chemopotentiation via inhibition of DNA repair processes. Flap endonuclease 1 (FEN1) is a key enzyme involved in base excision repair (BER), a primary pathway utilized by mammalian cells to repair DNA damage. In this report, we describe the identification and SAR of a series of 2,4-diketobutyric acid FEN1 inhibitors.
Keywords
fax: +1-216-3619495 , e-mail: ntumey@athersys.com , endonuclease , cancer , FEN1.* Corresponding author. Tel.: +1-216-4319900x498
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2004
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
794899
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