Title of article :
Synthesis and biological evaluation of novel cytotoxic phospholipids for prostate cancer
Author/Authors :
Veeresa Gududuru، نويسنده , , Eunju Hurh، نويسنده , , Gangadhar G. Durgam، نويسنده , , Seoung-Soo Hong، نويسنده , , Vineet M. Sardar، نويسنده , , Huiping Xu، نويسنده , , James T. Dalton، نويسنده , , Duane D. Miller، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2004
Abstract :
We describe herein synthesis, SAR, and biological evaluation of a novel series of cytotoxic serine amide phosphates (SAPs) for prostate cancer. These compounds were tested for their cytotoxicity in five human prostate cancer cell lines (DU-145, PC-3, LNCaP, PPC-1, and TSU), and in CHO and RH7777 cells (negative controls). Comparison of anticancer effects of these compounds with a standard chemotherapeutic agent 5-fluorouracil shows that they are very effective in killing prostate cancer cells with low micromolar cytotoxicity and provide us a new lead for the development of drugs for prostate cancer.
Keywords :
DC , July 11–14 , prostate cancer , LPA , New agents , Cytotoxicity.qPart of this work was presented at 225th ACS National Meeting , New Orleans , LA , March 23–27 , 2003 and at 94th Annual AACRMeeting , Washington , 2003.
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
