Title of article :
Synthesis and GABA receptor potency of 3-thiomethyl-4-(hetero)aryl-5-amino-1-phenylpyrazoles
Author/Authors :
Sanath K. Meegalla، نويسنده , , Dario Doller، نويسنده , , DeYou Sha، نويسنده , , Rich Soll، نويسنده , , Nancy Wisnewski، نويسنده , , Gary M. Silver، نويسنده , , Dale Dhanoa، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2004
Abstract :
A convenient synthetic route to novel 4-arylpyrazoles is described. The potential for insecticidal activity through GABA channel blockage by this series of compounds, as well as their selectivity for insect versus mammalian receptors, are explored through in vitro and in vivo assays.
Keywords :
Insecticidal activity.* Corresponding author. Tel.: +1-610-458-8959 , GABA , Aryl pyrazole , fax: +1-610-458-8249 , e-mail: smeegalla@prdus.jnj.com
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
