Title of article
Synthesis and GABA receptor potency of 3-thiomethyl-4-(hetero)aryl-5-amino-1-phenylpyrazoles
Author/Authors
Sanath K. Meegalla، نويسنده , , Dario Doller، نويسنده , , DeYou Sha، نويسنده , , Rich Soll، نويسنده , , Nancy Wisnewski، نويسنده , , Gary M. Silver، نويسنده , , Dale Dhanoa، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2004
Pages
5
From page
4949
To page
4953
Abstract
A convenient synthetic route to novel 4-arylpyrazoles is described. The potential for insecticidal activity through GABA channel blockage by this series of compounds, as well as their selectivity for insect versus mammalian receptors, are explored through in vitro and in vivo assays.
Keywords
Insecticidal activity.* Corresponding author. Tel.: +1-610-458-8959 , GABA , Aryl pyrazole , fax: +1-610-458-8249 , e-mail: smeegalla@prdus.jnj.com
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2004
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
794906
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