Title of article
Synthesis of enantiomerically pure d-FDOC, an anti-HIV agent
Author/Authors
Shuli Mao، نويسنده , , Martin Bouygues، نويسنده , , Christopher Welch، نويسنده , , Mirlinda Biba، نويسنده , , Jen Chilenski، نويسنده , , Raymond F. Schinazi، نويسنده , , Dennis C. Liotta، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2004
Pages
4
From page
4991
To page
4994
Abstract
The β-d-enantiomer of FDOC (2′,3′-dideoxy-5-fluoro-oxacytidine) exhibits potent anti-HIV-1 activity. It was obtained in optically pure form by employing a tandem kinetic resolution/chiral salt crystallization protocol. In addition, conditions were developed that allowed the unwanted butyrate ester of the l-enantiomer of FDOC to be racemized. This material could then be recycled in future resolutions.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2004
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
794914
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