Title of article :
1,3-Dihydro-2,1,3-benzothiadiazol-2,2-diones and 3,4-dihydro-1H-2,1,3-benzothidiazin-2,2-diones as ligands for the NOP receptor
Author/Authors :
R. Richard Goehring، نويسنده , , John F.W. Whitehead، نويسنده , , K. Brown، نويسنده , , Khondaker Islam، نويسنده , , Xin Wen، نويسنده , , Xiaoming Zhou، نويسنده , , Zhengming Chen، نويسنده , , Kenneth J. Valenzano، نويسنده , , Wendy S. Miller، نويسنده , , Yan-Shen Shan، نويسنده , , Donald J. Kyle، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2004
Abstract :
A series of 1,3-dihydro-2,1,3-benzothiadiazol-2,2-diones (I) and 3,4-dihydro-1H-2,1,3-benzothidiazin-2,2-diones (II) were prepared. While the five-member ring series (I) did not show good affinity for opioid receptors, the six-member ring series (II) exhibited extremely high affinity and selectivity for the NOP receptor and showed full agonist activity, as determined by stimulation of GTPγ[35S] binding.
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
