Title of article
Synthesis and cytotoxic activity of novel derivatives of 4′-demethylepipodophyllotoxin
Author/Authors
Shi-Wu Chen، نويسنده , , Xuan Tian، نويسنده , , Yong-Qiang Tu، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2004
Pages
4
From page
5063
To page
5066
Abstract
Nine novel 4β-N-substituted-5-FU-4′-demethylepipodophyllotoxin derivatives were synthesized and evaluated as potential antitumor agents. All of the target compounds showed more significant cytotoxic activity against HL-60 and A-549 in vitro than VP-16 and 5-FU. Among them, 4β-N-substituted-phenylalanine 5-Fu pentyl ester-4′-demethylepipodophyllotoxin (9g) was found to exhibit most potent cytotoxic activity against HL-60 and A-549 cell (IC50 is 0.04 and <0.01 μM, respectively).
Keywords
5-FU , Podophyllotoxin , Antitumor drugs.* Corresponding authors. Tel.: +86 931 8912410 , fax: +86 9318912582 , e-mail addresses: tuyq@lzu.edu.cn , xuant@lzu.edu.cn , amino acid
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2004
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
794927
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