Author/Authors :
Joseph Dudash Jr.، نويسنده , , Xiaoyan Zhang، نويسنده , , Roxanne E. Zeck، نويسنده , , Sigmond G. Johnson، نويسنده , , Geoffrey G. Cox، نويسنده , , Bruce R. Conway، نويسنده , , Philip J. Rybczynski، نويسنده , , Keith T. Demarest، نويسنده ,
Abstract :
A series of glucose conjugates was synthesized and tested for inhibition of SGLT1 and SGLT2. The core structure was derived from compound 1a. Modification of the benzofuran moiety and 4′-substituent of the phenyl ring in compound 1a improved selectivity at SGLT2. Select compounds were compared to 1a in metabolic stability and in vivo efficacy studies.
