Title of article
Induction of G2/M cell cycle arrest and apoptosis by a benz[f]indole-4,9-dione analog in cultured human lung (A549) cancer cells
Author/Authors
Eun-Jin Lee، نويسنده , , Hyun-Jung Lee، نويسنده , , Hyen Joo Park، نويسنده , , Hye Young Min، نويسنده , , Myung-Eun Suh، نويسنده , , Hwa-Jin Chung، نويسنده , , Sang Kook Lee، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2004
Pages
4
From page
5175
To page
5178
Abstract
A synthetic benz[f]indole-4,9-dione analog, 2-amino-3-ethoxycarbonyl-N-methylbenz[f]indole-4,9-dione (SME-6), showed a potent growth inhibition of a panel of human cancer cell lines. The mechanism of action study revealed that the growth inhibitory effect of SME-6 was highly related to the induction of G2/M cell cycle arrest and apoptosis in human lung cancer cells (A549). These data may provide new information for understanding the mechanisms by benz[f]indole-4,9-diones-mediated antitumor activity.
Keywords
9-dione , Apoptosis.* Corresponding author. Tel.: +82 2 32773023 , G2/M cell cycle arrest , fax: +82 2 32772851 , e-mail: sklee@ewfha.ac.kr
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2004
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
794950
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