Title of article
Synthesis and enzymatic evaluation of xanthine oxidase-activated prodrugs based on inhibitors of thymidine phosphorylase
Author/Authors
Philip Reigan، نويسنده , , Abdul Gbaj، نويسنده , , Edwin Chinje، نويسنده , , Ian J. Stratford، نويسنده , , Kenneth T. Douglas، نويسنده , , Sally Freeman، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2004
Pages
4
From page
5247
To page
5250
Abstract
A series of xanthine oxidase-activated prodrugs of known inhibitors of thymidine phosphorylase are described. These prodrugs were oxidised by xanthine oxidase at C-2 and/or C-4 of the uracil ring to generate the desired TP inhibitor. The scheme shows the prodrug of TPI.
Keywords
Thymidine phosphorylase , Xanthine oxidase , Inhibitor.* Corresponding author. Tel.: +44 (0)161 275 2366 , prodrug , fax: +44 (0)161 275 2396 , e-mail: sally.freeman@man.ac.uk
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2004
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
794964
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