Title of article :
Optimizing the antibacterial activity of a lead structure discovered by ‘SAR by MS’ technology
Author/Authors :
Elizabeth A. Jefferson، نويسنده , , Punit P. Seth، نويسنده , , Dale E. Robinson، نويسنده , , Dana K. Winter، نويسنده , , Alycia Miyaji، نويسنده , , Lisa M. Risen، نويسنده , , Stephen A. Osgood، نويسنده , , Myra Bertrand، نويسنده , , Eric E. Swayze، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2004
Abstract :
We report on lead optimization of a compound that was originally discovered to bind bacterial 23S rRNA near the L11 binding site and inhibit translation in vitro, but lacked detectible antibacterial activity. In this study, we were able to generate compounds with antibacterial activity against Gram-negative and Gram-positive pathogens, including a methicillin-resistant S. aureus strain.
Keywords :
RNA , Antibacterial , MIC.* Corresponding author. Tel.: +1 760 603 2533 , fax: +1 760 6034654 , e-mail: ejeffers@isisph.com , biaryl
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
