Title of article
Optimizing the antibacterial activity of a lead structure discovered by ‘SAR by MS’ technology
Author/Authors
Elizabeth A. Jefferson، نويسنده , , Punit P. Seth، نويسنده , , Dale E. Robinson، نويسنده , , Dana K. Winter، نويسنده , , Alycia Miyaji، نويسنده , , Lisa M. Risen، نويسنده , , Stephen A. Osgood، نويسنده , , Myra Bertrand، نويسنده , , Eric E. Swayze، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2004
Pages
5
From page
5257
To page
5261
Abstract
We report on lead optimization of a compound that was originally discovered to bind bacterial 23S rRNA near the L11 binding site and inhibit translation in vitro, but lacked detectible antibacterial activity. In this study, we were able to generate compounds with antibacterial activity against Gram-negative and Gram-positive pathogens, including a methicillin-resistant S. aureus strain.
Keywords
RNA , Antibacterial , MIC.* Corresponding author. Tel.: +1 760 603 2533 , fax: +1 760 6034654 , e-mail: ejeffers@isisph.com , biaryl
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2004
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
794966
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