Author/Authors :
Vinod R. Hegde، نويسنده , , Haiyan Pu، نويسنده , , Mahesh Patel، نويسنده , , Pradip R. Das، نويسنده , , Julie Strizki، نويسنده , , Vincent P. Gullo، نويسنده , , Chuan-Chu Chou، نويسنده , , Alexei V. Buevich، نويسنده , , Tze-Ming Chan، نويسنده ,
Abstract :
The 70% aqueous methanol extract of the Peruvian plant Lippia alva (Verbenaceae) was found to contain three novel compounds, 1, 2, and 3, which were identified as inhibitors of the chemokine receptor CCR5. The structures of 1–3 were established based on extensive NMR studies. Compounds 1–3 inhibited CCR5 receptor signaling as measured by a calcium mobilization assay with IC50 values of 5.5, 6.0, and 7.2 μg/mL, respectively.
