Title of article :
Novel histone deacetylase inhibitors: cyclic tetrapeptide with trifluoromethyl and pentafluoroethyl ketones
Author/Authors :
Binoy Jose، نويسنده , , Yusuke Oniki، نويسنده , , Tamaki Kato، نويسنده , , Norikazu Nishino، نويسنده , , Yuko Sumida، نويسنده , , Minoru Yoshida، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2004
Abstract :
Cyclic tetrapeptides containing trifluoromethyl and pentafluoroethyl ketone as zinc binding functional group were synthesized as potent HDAC inhibitors. Evaluation by human HDAC inhibition assay and p21 promoter assay showed that these inhibitors are promising anticancer agents.
Keywords :
Histone deacetylase , inhibitor , Cyclic tetrapeptide , Trifluoromethylketone , Pentafluoroethyl ketone.* Corresponding author. Tel./fax: +81936956061 , e-mail: nishino@life.kyutech.ac.jp
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
