Title of article
Examining the correlations between GSK-3 inhibitory properties and anti-convulsant efficacy of valproate and valproate-related compounds
Author/Authors
Geoff H. Werstuck، نويسنده , , Anna J. Kim، نويسنده , , Timothy Brenstrum، نويسنده , , Stephan A. Ohnmacht، نويسنده , , Ella Panna، نويسنده , , Alfredo Capretta، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2004
Pages
3
From page
5465
To page
5467
Abstract
A family of compounds based upon the chemical structure of valproate were synthesized and assayed for their ability to inhibit glycogen synthase kinase (GSK)-3 α and β activity in vitro. This data is correlated to the known anti-convulsant properties of these compounds in order to determine the potential role of GSK-3 inhibition in the therapeutic efficacy of these drugs.
Keywords
GSK-3 , Valproate.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2004
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
795004
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