Title of article :
Azaadamantane benzamide 5-HT4 agonists: gastrointestinal prokinetic SC-54750
Author/Authors :
Daniel P. Becker، نويسنده , , Daniel L. Flynn، نويسنده , , Robert L. Shone، نويسنده , , Gary Gullikson، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2004
Abstract :
Azaadamantanone 1 was converted to a series of aminoazaadamantane benzamides 9a–d, which were profiled for serotonin receptor activity. Aminomethylazaadamantane SC-54750 is a potent 5-HT4 agonist and 5-HT3 antagonist with in vivo efficacy in gastroparesis models and also inhibits cisplatin-induced emesis.
Keywords :
fax: +1 8477303181 , USA. Tel.: +1 8477297455 , e-mail:dbecke3@luc.edu , Serotonin , 5-HT3 , Prokinetic , 5-HT4 , Azaadamantane.* Corresponding author at present address: Department of Chemistry , IL 60626 , 6525 North Sheridan Road , Loyola University , Chicago
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
