Title of article :
Novel fibrinogen receptor antagonists. RGDF mimetics, derivatives of 4-(isoindoline-5-yl)amino-4-oxobutyric acid
Author/Authors :
Andrei A. Krysko، نويسنده , , Boris M. Chugunov، نويسنده , , Olga L. Malovichko، نويسنده , , Sergei A. Andronati، نويسنده , , Tatyana A. Kabanova، نويسنده , , Tamara L. Karaseva، نويسنده , , Anna V. Kiriyak، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2004
Abstract :
The novel RGDF mimetics 9a and 9b were synthesized with the use of 4-(isoindoline-5-yl)amino-4-oxobutyric acid as a surrogate of Arg-Gly motif. The synthesized compounds have demonstrated a high potency to inhibit platelet aggregation in vitro and to block FITC-Fg binding to αIIbβ3 on washed human platelets.
Keywords :
Fibrinogen receptor antagonists , Platelet aggregation.* Corresponding author. Tel.: +38 0482 663041 , RGD mimetics , Isoindoline , GP IIb/IIIa , e-mail: peptides@paco.net , fax: +38 0482652012
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
