Author/Authors :
Bradley Newhouse، نويسنده , , Shelley Allen، نويسنده , , Benjamin Fauber، نويسنده , , Aaron S. Anderson، نويسنده , , C. Todd Eary، نويسنده , , Joshua D. Hansen، نويسنده , , Justin Schiro، نويسنده , , John J. Gaudino، نويسنده , , Ellen Laird، نويسنده , , David Chantry، نويسنده , , Christine Eberhardt، نويسنده , , Laurence E. Burgess، نويسنده ,
Abstract :
A series of racemic and chiral, nonracemic lactams that display high binding affinities, functional chemotaxis antagonism, and selectivity toward CCR4 are described. Compound 41, which provides reasonably high blood levels in mice when dosed intraperitoneally, was identified as a useful pharmacological tool to explore the role of CCR4 antagonism in animal models of allergic disease.
Keywords :
lactams , CCR4 , Antagonists.* Corresponding author. Tel.: +1 303 381 6686 , fax: +1 303 3816652 , e-mail: lburgess@arraybiopharma.com
