Title of article :
Novel 2-oxoimidazolidine-4-carboxylic acid derivatives as Hepatitis C virus NS3-4A serine protease inhibitors: synthesis, activity, and X-ray crystal structure of an enzyme inhibitor complex
Author/Authors :
Ashok Arasappan، نويسنده , , F. George Njoroge، نويسنده , , Tejal N. Parekh، نويسنده , , Xiaozheng Yang، نويسنده , , John Pichardo، نويسنده , , Nancy Butkiewicz، نويسنده , , Andrew Prongay، نويسنده , , Nanhua Yao، نويسنده , , Viyyoor Girijavallabhan، نويسنده ,
Abstract :
Synthesis and HCV NS3 serine protease inhibitory activity of some novel 2-oxoimidazolidine-4-carboxylic acid derivatives are reported. Inhibitors derived from this new P2 core exhibited activity in the low μM range. X-ray structure of an inhibitor, 15c bound to the protease is presented.
