Title of article
Unprecedented olefin-dependent histidine–kinase inhibitory of zerumbone ring-opening material
Author/Authors
Takashi Kitayama، نويسنده , , Risa Iwabuchi، نويسنده , , Shu Minagawa، نويسنده , , Fumihiro Shiomi، نويسنده , , John Cappiello، نويسنده , , Seiji Sawada، نويسنده , , Ryutaro Utsumi، نويسنده , , Tadashi Okamoto، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2004
Pages
4
From page
5943
To page
5946
Abstract
Zerumbone ring-opening derivative, 4 (10E/10Z = 3/2), inhibited autophosphorylation of the essential histidine–kinase YycG existing in Bacillus subtilis constituting a two-component system (TCS). Generation of 4E-form could be regulated chemically using the difference from the ring-opening reactivity of the precursor forming of 4 and pure 4E was isolated. The stereoisomer, 4E, showed main inhibition activity of autophosphorylation of YycG (IC50 = 63.5 μM).
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2004
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
795100
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