Title of article :
Isosteric N-arylpiperazine replacements in a series of dihydropyridine NPY1 receptor antagonists
Author/Authors :
Guanglin Luo، نويسنده , , Gail K. Mattson، نويسنده , , Marc A. Bruce، نويسنده , , Henry Wong، نويسنده , , Brian J. Murphy، نويسنده , , Daniel Longhi، نويسنده , , Ildiko Antal-Zimanyi، نويسنده , , Graham S. Poindexter، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2004
Abstract :
4-Amino-N-arylpiperidines serve as effective bioisosteres for N-arylpiperazines in the series of dihydropyridine NPY1 receptor antagonists. These were prepared by a ZnCl2-mediated reductive amination reaction between elaborated primary amines, 2 or 5, and 4-arylpiperidones.
Keywords :
NPY1 receptor antagonists.* Corresponding author. Tel.: +1 203 677 6640 , fax: +1 203 6777702 , e-mail: guanglin.luo@bms.com , Bioisostere , N-arylpiperazine
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
