Author/Authors :
Shawn P. Maddaford، نويسنده , , Mina Motamed، نويسنده , , Kevin B. Turner، نويسنده , , Min Soo K. Choi، نويسنده , , Jailall Ramnauth، نويسنده , , Suman Rakhit، نويسنده , , Robert R. Hudgins، نويسنده , , Daniele Fabris، نويسنده , , Philip E. Johnson، نويسنده ,
Abstract :
We report the identification of a novel compound that binds to the Escherichia coli 16S ribosomal A-site. Binding by the compound was observed using nuclear magnetic resonance and mass spectrometry techniques. We show that the compound binds in the same position in the A-site RNA as occupied by the aminoglycoside class of antibiotics.
Keywords :
rRNA , RNA–ligand interactions , NMR spectroscopy , Docking. , mass spectrometry
