Title of article
Chimeric cyclodepsipeptides as mimetics for the anthelmintic PF1022A
Author/Authors
Hubert Dyker، نويسنده , , Achim Harder، نويسنده , , Jürgen Scherkenbeck، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2004
Pages
4
From page
6129
To page
6132
Abstract
In the anthelmintic cyclooctadepsipeptide PF1022A (1) didepsipeptide units have been exchanged for the β-turn mimetics (d)-Pro-(l)-Pro and BTD (7) in order to elucidate the functional role of the depsipeptide backbone. Compounds 12 and 14 are the first PF1022A analogues in which a substantial part of the PF1022A backbone has been replaced with an improvement of anthelmintical activity. Preliminary structure–activity relationships suggest a symmetric conformation to be the biological active one.
Keywords
anthelmintic , Cyclooctadepsipeptide , PF1022A , Turnmimetic.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2004
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
795139
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