Title of article
Anti-coxsackievirus B3 activity of 2-amino-3-nitropyrazolo[1,5-a]pyrimidines and their analogs
Author/Authors
Vadim A. Makarov، نويسنده , , Olga B. Riabova، نويسنده , , Vladimir G. Granik، نويسنده , , Hans-Martin Dahse، نويسنده , , Axel Stelzner، نويسنده , , Peter Wutzler، نويسنده , , Michaela Schmidtke، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2005
Pages
3
From page
37
To page
39
Abstract
A novel class of 2-amino-4-nitropyrazolo[1,5-a]pyrimidines has been identified as potent inhibitors of coxsackievirus B3 replication. The synthesis of these compounds is based on the regioselective reaction of 3,5-diamino-5-nitropyrazole with unsymmetrical β-diketones at catalysis by hydrochloric acid leading to 2-amino-4-nitropyrazolo[1,5-a]pyrimidines as key steps.
Keywords
5-a]pyrimidines , antiviral , Coxsackievirus
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2005
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
795145
Link To Document